Good Samaritan College of Nursing and Health Science has adapted to serve the evolving needs of both aspiring health care professionals and the Greater Cincinnati community for over 114 years. The College is committed to being the regional leader in providing nursing and health care education in a unique Catholic and hospital-based college environment.

• 1852: St. John’s Hotel for Invalids established after Archbishop John Purcell donated a small hospital building located at Broadway and Woodward to the Sisters of Charity.
• 1866: Two local bankers, impressed with the medical care given to a friend, purchased a 95-bed hospital at Sixth and Lock. This institution was named the Hospital of the Good Samaritan and donated to the Sisters of Charity.
• 1896: Good Samaritan School of Nursing was established. The first graduates (there were eight!) received diplomas three years later. Since then, more than 6,000 nurses have graduated from the institution.
• 1915: The hospital and school moved to the current Clifton site.
• 1942: The school was granted NLNE conditional Accreditation (the National League for Nursing Education was the precursor to the current National League for Nursing Accrediting Commission).
• 1945: The school was granted full accreditation with the NLNE, (1 of only 100 out of 1300 schools in the country at the time).
• 2001: The Good Samaritan College of Nursing and Health Science was formed as a private independent college and received approval from the Ohio Board of Regents and the Ohio Board of Nursing to grant the Associate of Applied Science in Nursing degree.
• 2006: GSC was accredited by the Higher Learning Commission and became a member of the North Central Association.
• 2006: GSC's Nursing Program was accredited by the National League for Nursing Accrediting Commission.
• 2011: GSC was reaccredited by the Higher Learning Commission, a member of the North Central Association, and the National League for Nursing Accrediting Commission for the maximum periods allowable.
• 2012: GSC was authorized by the Ohio Board of Regents to grant a Bachelor of Science in Nursing (BSN) degree and an Associate of Science in Health Science degree.
• 2013: GSC was accepted by the Higher Learning Commission to grant a Bachelor of Science in Nursing (BSN) degree and an Associate of Science in Health Science  (ASHS) degree.